Atypical Antipsychotics: Mechanism of Action
نویسندگان
چکیده
منابع مشابه
Atypical antipsychotics: mechanism of action.
BACKGROUND Although the principal brain target that all antipsychotic drugs attach to is the dopamine D2 receptor, traditional or typical antipsychotics, by attaching to it, induce extrapyramidal signs and symptoms (EPS). They also, by binding to the D2 receptor, elevate serum prolactin. Atypical antipsychotics given in dosages within the clinically effective range do not bring about these adve...
متن کاملTheoretical insights into the mechanism of action of atypical antipsychotics.
The present work discusses some theoretical mathematical results that can be derived from the theory of receptor binding linked with PET experimental data and presents insights to the understanding of the differences between typical and atypical profile of antipsychotics regarding the generation of extrapyramidal syndrome. The first part of the paper discusses the importance of the drug affinit...
متن کامل"Hit-and-run" actions at dopamine receptors, part 1: Mechanism of action of atypical antipsychotics.
Either 5-HT2A antagonism or fast dissociation from D2 receptors may define an atypical antipsychotic. To have little or no motor symptoms from an antipsychotic, it is clear that D2 receptor binding in the striatum must be less than that caused by conventional antipsychotics. Pure 5-HT2A antagonism by itself does not result in robust antipsychotic actions. However, 5-HT2A antagonism can reduce D...
متن کاملMechanism of Action of Atypical Antipsychotic Drugs
The designation of chlorpromazine, and subsequently haloperidol, thioridazine, loxapine, thiothixene, molindone, pimozide, and related compounds as antipsychotic drugs (1) reflects their predominant action in humans, namely the suppression of auditory hallucinations and delusions, in some, but not all, individuals with diagnoses of schizophrenia as well as other psychoses. These drugs are also ...
متن کاملAtypical antipsychotics and parkinsonism.
BACKGROUND Atypical antipsychotic agents are thought to be less likely than older typical agents to produce parkinsonism. This has not been well documented. We compared the risk of development of incident parkinsonism among older adults dispensed atypical relative to typical antipsychotics. METHODS Retrospective cohort study of all adults 66 years and older in Ontario. We used Cox proportiona...
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ژورنال
عنوان ژورنال: The Canadian Journal of Psychiatry
سال: 2002
ISSN: 0706-7437,1497-0015
DOI: 10.1177/070674370204700106